Things You Should Know About Fenbendazole

Fenbendazole

Fenben, or Panacur as it is also known, is an antihelmintic of the benzimidazole type. Since its discovery in 1975, it has been used worldwide. In the past few decades, fenbendazole and similar drugs have shown a significant impact on cancer. (Ref.1, Ref.2)

This led to the theory that this de-wormer listed for dogs could be used as an anti-cancer medicine. In fact, the benzimidazole-class drugs can perform in a similar way to a wide range of contemporary chemotherapy medications such as Taxol and Vinca alkaloids. ( Refer. ) Available toxicological data suggests that fenbendazole is well tolerated by humans after oral contact. However, there are only a few human studies. (Ref.)

Fenbendazole powder is usually available unadulterated and has a white color with a weak solubility in water.

This drug is not well absorbed in the bowels. Food in the stomach may increase bioavailability.

What is the mechanism of action of fenbendazole?

Fenbendazole is a drug that was originally intended to treat parasites. It works by inhibiting microtubule production through a specific attachment to b-tubulin. This prevents the polymerization and death of parasite cells by b-tubulin dimers.

It's amazing to see that fenbendazole and other benzimidazoles have a similar effect on tumor cells. There are currently three main methods that fenbendazole uses to destroy cancer cells.

Induction of apoptosis. The anti-tumor effects are thought to be achieved by combining the medicine with b-tubulin. This leads to the stopping of the cell cycle and is cytotoxic.

It has been shown that benzimidazole-carbamates can stop tubulin polymerization in microtubules in helminths and human tumor cells. (Ref.1, Ref.2)

The use of glucose by cancer cells is known to be excessive. The Warburg effect means that cancer cells use glucose 200 times faster than normal cells. PET scans reveal this – metabolically active sites that consume additional radioactive glucose are clearly visible and believed to be cancerous tumors or inflammation.

Fenbendazole reduces sugar consumption by cancer cells through a reduction in GLUT transporters, which are channels that deliver glucose from the blood into cancerous cancerous cell. It also inhibits the enzyme Hexokinase 2. Hexokinase is essential for cancer cell survival. It helps tumours grow by producing more sugar and accelerating lactic acidosis in the extracellular matrix. (Ref.1, Ref.2)

In addition, restarting p53 prevents the production of fuel for cancer. When p53 returns, it stops the expression and action of GLUT1 (glucose gate) transporters in cells. (Ref.)

The revival of the p53-gene. Although this work is controversial, additional studies are needed to prove that fenbendazole causes such an action. (Ref.)

There is a growing amount of research that has confirmed that fenbendazole can actually boost the strongest tumour suppressor in the body – the p53. (Ref.)

Elephants have twenty copies of the gene p53 in their genome, but humans only have one. It's strange that an elephant gets cancer less frequently than a person. These animals are large, but they also have a greater number of cells and a higher amount of genetic mutations.

It is interesting to note that cancer cells are able to adapt to the de-wormer drug and escape it. This occurs in a number of chemotherapy and biological therapies.

Cancer cells can become resistant to chemotherapy when they adapt to the ability to excrete medications by themselves, through drug efflux pumps called P-glycoproteins. Fenbendazole doesn't target p-glycoproteins and therefore can't be ejected from cancer cells once it's in there.

The tumors will not develop any resistance to fenbendazole. It is still effective and will continue to destroy cancer cells. This is not the case with paclitaxel or other chemotherapies such as vinblastine, Docetaxel, Vincristine, etc. (Ref.)

The image below shows the Dogra 2018 (Dogra 2018).

Fenbendazole is a radiotherapy agent that can sensitize tumours in a similar way to taxane-based chemotherapy agents. [22].

***Fenbendazole is a microtubule-disrupting agent that can cause cancer cells to die.

Fenbendazole dose guide

Protocol – complementary treatment for cancer

Fenbendazole (222 mg): Take one capsule three times weekly after a fat dinner. * Do not take it for four days. Repeat this cycle every week.
Vitamin E 800 U/I. Take one capsule, or any other form of Vitamin E 800 U/I daily without waiting.
Take one capsule after breakfast and lunch, without waiting.
CBD oil 25 milligrams. Take one or two drops of CBD oil (totaling 25mg) daily under the tongue before going to bed.

*- Fenbendazole, which is hydrophobic in nature, is not well absorbed by the bowels. It is better absorbed if you consume it with food.

Protocol (the modified, stronger version): complementary cancer treatment

Fenbendazole 222 milligrams. Take one capsule every day after a meal high in fat. **
Vitamin E 800 U/I. Take one capsule daily or any other form.
Take one capsule after breakfast and lunch, without waiting.
CBD oil 25 milligrams Take one or two drops of CBD oil (totaling 25mg) daily under the tongue.

Fenbendazole has a low toxicity for people who do not have liver or kidney problems.

Prophylactic treatment to prevent cancer relapse

Fenbendazole 222 milligrams. Take one capsule daily, 3x per week after a meal high in fat. After 4 days, stop taking it. Repeat this cycle every week.
Vitamin E 800 U/I. Take one capsule daily or another version after you eat without stopping.
Bio-Available Curcumin 600 milligrams. Take one capsule after breakfast and lunch.
CBD oil 25 milligrams Take one or two drops of CBD oil (total25 milligrams per day) under the tongue before bedtime.
Routine annual cancer imaging tests, including regular checks of tumour markers every few months. Reduce the frequency of tests if there is no cancer relapse in five years.

Prophylactic treatment to prevent cancer in someone who has never had cancer

Fenbendazole 222 milligrams. Take one capsule daily, 3x per week after a meal high in fat. After 4 days, stop taking it. Repeat this process for ten weeks. Stop for ten week. Repeat the cycle.
Vitamin E 800 U/I. Take one capsule daily, or another kind of vitamin E product.
Bio-Available Curcumin 600 milligrams. Take one capsule after breakfast and lunch, without stopping.
CBD oil 25 milligrams Take one or two drops of CBD oil (25 milligrams total) daily under the tongue.

Side effects and safety of Fenbendazole

Based on toxicology, benzimidazoles such as Fenbendazole and Albendazole appear to be safe medicines.

A medication without side effects does not exist. Fenbendazole consumption does not cause any significant adverse reactions according to scientific information. There are still some reports of possible toxicity.

Five percent of people can experience stomach pains or loose bowels after consuming large quantities of fenbendazole.
In people with severe kidney or liver disease, the excretion of medication is reduced. As a result, fenbendazole can build up, leading to unexpected side effects. Divide the doses according to your situation.

It was designed to keep the liver healthy. Three days of treatment and four days off are recommended.
Fenbendazole is metabolized primarily in the liver, so if it's used for long periods of time without a break and in large amounts, this can cause asymptomatic increases in liver enzymes. The effect can be reversed by taking a two-week break.

The procedure was designed to keep the liver healthy. Therefore, a schedule of taking the medication three days a week and not taking it for four days is recommended.

More and more people are taking fenbendazole five days at a time, followed by two days without taking it.

We recommend that you take Silymarin 150 milligrams or 250 milligrams every day to keep your liver in top shape.

Fenbendazole Clinical Trials and Papers

There is also a section for pre-clinical research, in vitro cancer studies, and clinical trials. Analyze accessible facts from published study information. This section is for information-hungry enthusiasts.

To find out more please visit our website: https://fenbenlab.com/

References

1) Fenbendazole is a moderately destabilizing microtubule agent that causes cancer cell death through modulation of multiple cellular pathways.

https://www.nature.com/articles/s41598-018-30158-6

Fenbendazole and Supplemental Vitamins: Unexpected Antitumorigenic Activity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687140/

Fenbendazole: A Potential Anticancer Drug

http://ar.iiarjournals.org/content/33/2/355.full

4) Mebendazole, an antihelmintic drug, induces mitotic arrest and apoptosis in non-small cell lung cancer by depolymerizing tubulin.

https://mct.aacrjournals.org/content/1/13/1201.long

Five-year pilot study of albendazole for patients with advanced cancer. Effect on serum tumour markers/high incidences of neutropenia.

https://www.ncbi.nlm.nih.gov/pubmed/11474247

6) In vitro and xenograft models of peritoneal cancertosis: antitumor activity against the human colorectal carcinoma cell line HT29.

https://www.ncbi.nlm.nih.gov/pubmed/15565325

Benzimidazole: A Novel Treatment for Metastatic Prostate Carcinoma Refractory to Hormones

https://apps.dtic.mil/dtic/tr/fulltext/u2/a545657.pdf

Mebendazole induces cell death via Bcl-2 deactivation in chemoresistant melanomas.

https://www.ncbi.nlm.nih.gov/pubmed/18667591

9) Phase 1 clinical trial to determine the maximum tolerated dosage of oral albendazole for patients with advanced cancer.

https://link.springer.com/article/10.1007%2Fs00280-009-1157-8

Repurposing Drugs in Oncology — Mebendazole, as an anticancer agent.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/

The Potential of Flubendazole in Cancer Therapy.

https://pdfs.semanticscholar.org/2b47/0bf133be75b36c09ebc8b17e70cea85fd9af.pdf

12 ) Chronic myelogenous lymphoma in a great-horned Owl (Bubo Virginianus)

https://www.ncbi.nlm.nih.gov/pubmed/19530405

13) Dogra N. (2018 August 9). Fenbendazole is a moderately microtubule-destabilizing agent that causes cancer cell death through modulation of multiple cellular pathways. Scientific Reports. https://www.nature.com/articles/s41598-018-30158-6

14) Fenbendazole.org. (2019). Fenbendazole Dosage Guide And Calculator. Scientific Research. https://www.fenbendazole.org/fenbendazole-information/fenbendazole-dosage-guide/

Alternative Medicine Magazine published the article Things you should know about Fenbendazole.

Frequently Asked Questions

What are the strengths of holistic medicine compared to conventional medicine?

Many religions and cultures around the world have used holistic medicines for thousands of years. They were based upon ancient knowledge and experienced.

These medicines are safe, efficient, natural, and inexpensive. Side effects of these medicines are very low compared to pharmaceutical drugs.

They will also assist you in achieving better health and well-being.

They can reduce the risk of disease and increase your overall well-being.

They may even cure diseases such as cancer, diabetes, heart disease, arthritis, asthma, depression, anxiety, high blood pressure, etc.

There are many traditional medicines available, with each having its own benefits.

The World Health Organization estimates that 80% of the population relies on traditional methods to treat illness or injury.

According to reports, half a billion people use traditional herbal remedies as their primary healthcare.

The global market for complementary therapies is estimated to reach $22.2 billion by 2020.

People are increasingly looking for alternative medical options to avoid any side effects that may be associated with traditional treatments.

Complementary therapies are often used when other options fail to work. These complementary therapies can also be used before undergoing surgery or medication.

There are many good reasons to choose complementary therapies.

To improve the quality and quantity of your life
To reduce stress levels
Relaxation
To relieve pain
To enhance immunity
For support in coping with serious illnesses
To boost energy
To control weight
To maintain good nutrition
To improve sleep patterns
To deal with chronic diseases

Is holistic medical legitimate?

The answer is both yes and no. Yes. There are many medications that have been proven to be effective against various conditions. They can't treat all conditions. It all depends on your definition of “holistic.” It all depends on your definition of “holistic.” If you mean taking into consideration all aspects of a person's health, then it is true. But if you only mean using natural remedies instead of chemical ones, then it is not.

Some people claim that holistic medicine has been around since ancient times. This is false. Even though some healers from ancient Egypt, Greece, Rome and other countries used natural remedies, this was without any scientific knowledge.

It wasn't until after the Middle Ages that medical doctors began to study anatomy. Most Western countries have developed public hospitals, where doctors can provide medical care, by the end of the 19th-century.

Conventional medicine is today the dominant type of healthcare. However, many people still prefer to use complementary and alternative medicine. Many people find that alternative medicine works better than pharmaceutical drugs.

Some people find that they feel more relaxed when receiving massage therapy than tranquilizers. Others prefer healthy eating to prescription medication. Others still believe that regular exercise improves their bodies' performance.

What is the difference in alternative medicine and complementary medicine?

Alternative medicine refers to treatments not considered conventional by mainstream medical professionals but have been shown to provide benefits for certain conditions. These include homeopathy, acupuncture, aromatherapy and reflexology as well as traditional Chinese medicine (TCM), Ayurveda and naturopathy. Complementary Medicines are treatments that add to the treatment of conventional medicine. They may also be used in combination with it. These may include dietary supplements, such as vitamins and minerals, herbs, enzymes, enzymes, probiotics or other natural substances.

Both forms of medicine can be used but are not recommended by many doctors due to lack of evidence or safety concerns.

The best way to integrate CAM into patient care is not a consensus among health care professionals.

Many CAM practices are based on theories developed over thousands of years. But clinical trials in the past 20 years have suggested that these therapies might work.

As an example, several studies indicate that acupuncture may relieve pain. Similar to chemotherapy, preliminary data suggest that acupuncture can reduce nausea or vomiting. A number of studies also suggest that acupuncture might improve symptoms like irritable and fibromyalgia as well as chronic fatigue syndrome, Multiple Sclerosis, multiple sclerosis, migraines tension headaches, anxiety, and anxiety.

Some CAM treatments may also have therapeutic potential for diseases such as HIV/AIDS, diabetes and asthma, heart disease, heart disease, hypertension or Alzheimer's disease.

While there are still questions about the effectiveness of CAM in treating different ailments, most experts agree it is possible.

As a consequence, more people turn to CAM practitioners for relief of common illnesses.

Despite the popularity of alternative and complementary medicine, many people are still unsure what they mean.

How safe can holistic medicine be?

Holistic medicines can be safe as they don't contain harmful drugs and are natural remedies that people have used for centuries.

Many diseases have been treated with these herbs, including cancer, arthritis, chronic and severe pain, asthma, diabetes, high cholesterol, heart disease, obesity (obesity), depression, anxiety stress, insomnia as well sexual dysfunction and infertility.

Holistic medicines are also used by millions of people around the world who suffer from various kinds of diseases. These include homeopathy and acupuncture as well as chiropractic care, massage therapy, homeopathy, herbal treatments, biofeedback, yoga, meditation, hypnosis, nutrition counseling, physical exercise, and other complementary therapies. These therapies address the whole person, not just the symptoms.

What is Alternative Medicine and How Does It Work?

It's a method of healing that focuses more on prevention than treatment. It encourages people become educated consumers who are actively involved in improving their overall health and well-being.

Alternative medicine refers to any system of diagnosis and treatment that does not employ allopathic (conventional) medical practices.

What are alternative medicine examples?

Alternative medicine is a treatment that does not fit the criteria of mainstream medicine. These include traditional Chinese medicine, homeopathy, chiropractic, acupuncture, herbal medicines, nutritional therapy, and energy healing techniques such as reiki.

Alternative medicine may also include practices that are not supported by scientific evidence but have been used with great success in clinical practice. Meditation, yoga, aromatherapy and reflexology are some examples.

What are the five alternative medical systems?

The five alternative medicine systems include acupuncture, Ayurveda, homeopathy, energy healing, and aromatherapy.

Acupuncture uses fine needles inserted into specific points on the body to stimulate the flow of qi (energy) throughout the entire body.

Ayurvedic medicines is an ancient system to balance the three senses of air, fire,, and water. It involves diet and exercise, herbal remedies as well massage and meditation.

Homeopathic Medicine derives its name from the Greek homoios which means similarity and pathos which denotes disease. Homeopaths believe that all diseases have natural causes but not always symptoms. They use minute amounts of substances to treat their patients. These symptoms are very similar to what the patient experiences when they are sick.

Energy Healing can also be known by the names Reiki, EFT Rolfing and Therapeutic Touch. This therapy is based on the belief that each person is connected to a universal life force called Ki. We feel better when this Ki flows freely through our bodies. Energy healers work with touch and intention to restore harmony and balance between our mental, spiritual, and physical selves.

Aromatherapy uses essential oil extracted from plants for therapeutic purposes. Aromatherapists believe certain scents can influence mood and behavior. Lavender essential oil is used most often in aromatherapy.

Statistics

These studies found that 38.4% concluded positive or possibly positive effects for CAM (12.4%), 4.8% concluded no effect, 0.7% concluded harmful effects, and 56.6% concluded insufficient evidence. (en.wikipedia.org)
According to the World Health Organization, 80% of people use herbal medicine worldwide. (webmd.com)
In the 17% in which they disagreed, a third reader agreed with one of the initial readers to set a rating. (en.wikipedia.org)
According to a 2005 book by a US [116]Institute of Medicine panel, the number of RCTs focused on CAM has risen dramatically. (en.wikipedia.org)
The concept of regression toward the mean implies that an extreme result is more likely to be followed by a less extreme result. (en.wikipedia.org)

External Links

How To

How to get a job in Holistic Medicine

The field of holistic medicine continues to grow at an incredible rate. There are many ways you can pursue this career path. If you are serious about this career, it is best to return to school.

Several schools offer courses in holistic medicine. These include the National College for Complementary Medicines. They offer both undergraduate and postgraduate degrees. Many programs are available for medical professionals wishing to enter the field.

In addition, numerous online universities are offering holistic health classes as well. One such program is the Institute of Integrative Nutrition. This college provides students with many holistic health education tools.

Another option is to enroll in a traditional four-year college. Many colleges offer holistic healthcare courses. A Bachelor's Degree is offered by the University of California in Holistic Health Sciences.

You should take a nutrition course if you want to pursue a career in holistic medicine. NCCM recommends that students take a course in nutrition before they begin any professional training. Integrative medicine requires a thorough understanding of nutrition science.

Because holistic medicine emphasizes treating the whole person instead of just the symptoms, it takes more knowledge and skill to practice holistic medicine. Holistic medicine also requires understanding of how to evaluate different types and illnesses from a nutritional standpoint.

According to the NCCM nutritionists often work alongside doctors to give dietary advice to their patients. Some will even suggest supplements or diets based on the patient's specific condition.

Holistic practitioners need to be able to understand basic nutrition principles. This includes knowing the best foods and those that are not. It also means identifying nutrient deficiencies and other problems that may be causing them.

It is important to know that holistic practitioners may not be experts in nutrition. Some focus mainly on herbal treatments, while others concentrate solely on acupuncture. Still, others combine these two approaches into one treatment method.

However, most holistic practitioners recommend a diet rich in fruits, vegetables, nuts, seeds, and grains. They recommend eating lots of seafood and fish. They suggest avoiding processed foods and fast food restaurants. Instead, they urge people to eat organic whenever possible.

Holistic practitioners agree that a healthy diet can prevent illness. That said, there are some things about which they disagree. For instance, they don't believe that gluten causes celiac disease. They think that the disorder can be triggered by a lack or nutrients.

However, they agree that allergic reactions can be triggered by certain foods. Anaphylaxis is caused by shellfish and peanuts, according to them. They also caution against excessive caffeine intake.

Many holistic practitioners are able to use herbs to treat many illnesses. They avoid the use of pharmaceutical drugs. Because they believe that pharmaceutical drugs can only mask the problem, rather than solving it. They prefer natural remedies whenever possible.

Holistic practitioners offer a range of alternative therapies and often employ complementary methods. These include:

Acupuncture is a form of Chinese medicine that involves strategically placing needles in the skin. This stimulates the body’s healing process.
Herbal therapy- Holistic practitioners use herbs to treat many disorders in addition to acupuncture. Ginseng, a popular herb for this purpose, is one of the most common.
Homeopathy – Another type of traditional Chinese medicine is homeopathy. It's based on similar cures. Suppose you experience a symptom similar to one that occurs when someone else has a particular ailment. In such cases, it's important to find a remedy with the same ingredients that the original medication.
Massage therapy – Many holistic practitioners offer massage therapy in order to promote relaxation, stress reduction, and stress relief. They also claim that it helps improve blood circulation, increase energy levels and ease muscle tension.

You need to ensure that your needs are met when selecting a practitioner. If you want someone specializing in nutritional counseling, look for a practitioner with a degree in nutrition. You can also learn more about acupuncture by contacting a practitioner who is certified by the American Association of Oriental Medicine.

Ask your doctor if you have questions about holistic health care before making any decision. Your insurance provider may be able to provide information about which services you are covered.

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By: jbenson@innovisionhm.com
Title: Things You Should Know About Fenbendazole
Sourced From: alternativemedicine.com/cancer/facts-you-might-not-have-known-about-fenbendazole/
Published Date: Wed, 26 Jul 2023 01:08:04 +0000