I first became interested in vitamin D when I learned that it is not a vitamin. Instead, it is the only known substrate of a seco-steroid neuro-hormone that functions, like all steroids, by turning genes on and off.
That means it has as many different mechanisms of action as the genes it regulates. Moreover, vitamin D directly regulates hundreds, if not thousands, of the 21,000 coding genes of the human genome. Genes are responsible for making the proteins and enzymes the human body relies on for normal development and function.
The Link Between Autism and Vitamin D
Evidence that vitamin D is involved in the autism epidemic is mounting. In 2009, Life Extension Magazine published a detailed description of the vitamin D deficiency as it pertains to autism theory, and in 2010, a Scientific American article asked, “What if vitamin D deficiency is a cause of autism?’” In 2009, Emily Deans, MD, wrote an extensive piece in Psychology Today outlining the theory; and in 2010, Dennis Kinney, PhD, and colleagues at Harvard, endorsed the vitamin D connection to autism. In 2012, Eva Kočovská, PhD, and colleagues, with senior author professor Christopher Gillberg of the Gillberg Neuropsychiatric Institute in Sweden, reviewed the evidence supporting the vitamin D link to autism and called for “urgent research” into the connection.
I myself first published, and later extended, epidemiological and animal data connecting vitamin D deficiency with autism. My second article discusses some of the autism/vitamin D evidence such as the devastating effect gestational vitamin D deficiency has on developing brains.
For the last three years, I have been helping parents of autistic children correct their children’s vitamin D deficiencies. My very preliminary and unscientific impressions are that if the child takes enough vitamin D, along with the correct co-factors, about 25 percent of the parents report dramatic improvements in their child’s autistic symptoms; about 50 percent of parents report significant improvements; and 25 percent of parents report no change.
But how can vitamin D help autism—a condition that is highly heritable?
DNA Repair
Autism may be a genetic disease that isn't inherited, but how can that be? It appears that many small, new genetic mutations, such as those seen in autism, occur either in the womb or during early childhood. This theory explains the genetics of autism very nicely: These mutations are the most common genetic findings in autistic children.
Scientists have identified at least five vitamin D-dependent genes that direct DNA repair proteins. These proteins have only one job: fix your broken DNA. James Fleet and colleagues at Purdue University wrote an excellent article on how vitamin D helps prevent cancer, and he almost offhandedly mentioned DNA repair as one of vitamin D’s mechanisms of action in cancer. Likewise, other research has shown that vitamin D is responsible for protecting the genome from genetic damage.
Repairing the genome is just another one of vitamin D’s repair and maintenance functions. Once the body has enough vitamin D, including enough to overcome any inherited defect of the vitamin D system, all those little genetic repair train cars can chug happily along, fixing the multiple genetic variations—including, perhaps, those associated with autism.
DNA Protection
DNA protection differs from DNA repair because preventing DNA damage is preferable to repairing the damage once it has occurred. In 2001, researchers reported that vitamin D stabilizes chromosomal structure and prevents DNA double-stranded breaks. They concluded that the role of vitamin D in repairing gene mutation and DNA strand breaks is much more important than we originally thought.
Because some scientists think that vitamin D helps repair DNA, it’s not outlandish to think that vitamin D has a role in protecting DNA as well. Three scientists from the University of Sydney Medical School in Australia recently reviewed test tube animal and human studies in detail, concluding that vitamin D does appear to protect DNA from mutations. They went so far as to say that vitamin D deficiency is associated with DNA damage from various cellular stresses and that obtaining adequate vitamin D is important in preventing DNA damage.
This research supports my theory that the tiny, widespread mutations and DNA damage in those with autism are the effects of a genetically impaired vitamin D system interacting with inadequate amounts of vitamin D building blocks. This interaction causes DNA injury not to be repaired. These differences in DNA have confused geneticists for years because they assumed that any genetic abnormality in those with autism was a cause rather than an effect.
Anti-Inflammatory Actions
Some researchers believe that autism is a disease of neuro-inflammation and that vitamin D’s anti-inflammatory actions may profoundly counter that inflammation. Studies in animals show both direct and indirect anti-inflammatory effects of vitamin D involving both arms—adaptive and innate—of the immune system.
Recent research reveals that activated vitamin D exhibits multiple anti-inflammatory effects, such as inhibiting the synthesis and biological actions of pro-inflammatory prostaglandins—unsaturated fatty acids that cause inflammation, the levels of —which are elevated in those with autism. Vitamin D also exerts anti-inflammatory activity through the inhibition of nuclear factor-kappa B—NF-KB, a protein complex that is involved in abnormal, pro-inflammatory signaling in autistic brains.
Autoimmune actions
There are more than 160 human autoimmune diseases, and some people believe that many cases of autism are, in fact, autoimmune; a number of autoantibodies in the brain have been identified in autistic children. Furthermore, levels of such antibodies are directly associated with the severity of autism.
A recent study found that the level of one particular anti-neural autoantibody was inversely correlated with vitamin D levels. In the same study, 25-hydroxy vitamin D—a pre-hormone produced by the liver—had significant negative correlations with the Childhood Autism Rating Scale. These findings beg the question: Would vitamin D help autism by reducing the blood levels of autoantibodies in autistic children?
Neurotrophins
Neurotrophins are the family of proteins that induce the development, function, and survival of nerve and brain cells. Vitamin D upregulates neurotrophins, such as the nerve growth factor (NGF) and the glial cell-line derived neurotrophic factor (GDNF), up to a fivefold. Could vitamin D help autistic children by increasing neurotrophins, thus helping a damaged brain develop properly?
Antioxidants
Several research groups report that vitamin D upregulates the antioxidant glutathione in the brain. Because glutathione participates in the scavenging of oxidative byproducts and the chelation (capture and excretion) of heavy metals, it is involved in the brain detoxification process. Thus, in addition to functioning as a master antioxidant, glutathione acts to remove heavy metals such as mercury. Glutathione protects nerve cells and nerve conduction that is critical to mental processing. In this regard, its protective effects on toxins are particularly important.
Scientists have reported that recent gene-profiling has revealed several more antioxidants whose genes are directly upregulated by vitamin D. This includes thioredoxin reductase and superoxide dismutase, both of which, among other things, function as antioxidants and detoxification agents. Thus, extra vitamin D may upregulate a suite of antioxidants.
Various tenable mechanisms exist for how vitamin D could help children with autism. Be it via anti-inflammatory actions, anti-autoimmune activities, upregulation of neurotrophins, or stimulation of antioxidant pathways, adequate doses of vitamin D (enough to obtain natural levels of 50 to 80 ng/ml) may be a potential treatment for some cases of autism.
Mitochondrial Protection
Mitochondria are the power plants of the cells; every human cell has them. When they work properly, they transform sugar into an energy molecule called adenosine triphosphate (ATP). With autism, something is wrong with the mitochondria: About 1 in 20 people with autism have obvious mitochondrial disease. Perhaps as many as 1 in 3 are in the gray zone; their mitochondria are not fully working. However, the numbers could be even higher—mild mitochondrial dysfunction is hard to document.
Recently, scientists tested an activated vitamin D-like drug, paricalcitol, to see if it could protect mitochondria. Scientists purposefully injured mitochondria in two groups of lab animals—one group given a placebo and the other given activated vitamin D—by tying off the ureter (the tube connecting the kidney to the bladder). In the non-vitamin D group, the mitochondria were larger and misshapen in their interiors, indicating serious damage; these changes did not occur in the vitamin D group. Additionally, markers of mitochondrial damage reverted back to normal in paricalcitol-treated animals several hours after the ureter was untied, but not in the control group.
These results suggest that vitamin D may have a protective effect at the mitochondrial level. Because vitamin D is turned into activated vitamin D in the tissues, it seems likely that vitamin D could protect mitochondria in people with autism.
No Randomized Controlled Trials
There have been no randomized controlled trials, and just one open label trial, concerning the role of vitamin D in preventing or treating autism spectrum disorder (ASD). Parents who want to try it should do their research and thoroughly understand that other than a single open label clinical trial, as well as test tube, epidemiological, and animal studies, no randomized controlled trials exist showing such an effect. However, a well-designed randomized controlled trial of vitamin D in autism is currently waiting for funding in Australia.
As I said above, my very rough estimation is that around 75 percent of autistic children seem to respond at least somewhat to higher doses of vitamin D if given with the correct dose of co-factors, such as magnesium, zinc, boron, and vitamin K2. To date, I have noticed the following things predict a positive response:
- Reported seasonality of autistic symptoms for children with summer access to a swimming pool, or similar extensive outdoor activities with few clothes and without using sunblock, in which the child is much better in late summer than he or she is in late winter, usually respond.
- Children who had a period of early normal development, compared with those who seem affected even as infants, seem to respond better.
- Children with mild or moderate autism seem to respond better.
- Children younger than 8 seem to respond better than older children do.
None of these, except perhaps a very distinct seasonality of symptoms, clearly predicts a response to vitamin D. In the same vein, some parents have told me that children with infantile onset of symptoms, more severe autism, or children older than 8 have responded.
Unfortunately, my experience is that the 10 to 20 percent of children with known genetic causes of autism—such as Rett syndrome, fragile X syndrome, tuberous sclerosis, clear mitochondrial defects, submicroscopic deletions or duplications in DNA sequences, or deletions or duplications of chromosome regions—do not respond.
Parents can get the full story by reading my book, Autism Causes, Prevention and Treatment.
The post Vitamin D and Autism: The Missing Link appeared first on Alternative Medicine Magazine.
Frequently Asked Questions
What does holistic mean to you?
Holistic means whole-based. Holistic refers to looking at the whole picture, not just one part. This isn't always possible because we tend not to see things as a whole.
We tend to think in terms of black and white. However, grey comes in a wide range of shades.
Try to look at everything from different perspectives when you work on a project. You should look at it from all sides.
Consider how the whole thing fits together. How do its various elements interact with each other?
You should also ask yourself why the problem is occurring. And don't forget to consider the impact of any change you make.
What's the difference between holistic medicine, traditional medicine, and holistic?
Traditional medicine tends to treat symptoms while holistic medicine treats the entire person. Holistic medicine focuses on the whole person and not just one aspect of a patient's health.
Traditional medicine treats specific organs and systems, such as the brain. Holistic medicine examines the whole body from the inside. It considers the impact of lifestyle choices on overall wellness.
What are some of the benefits of complementary or alternative medicine?
People who feel they do not receive enough help from allopathic medicine may use complementary and alternative medicine (CAM). These therapies include herbs, mind-body treatments such as acupuncture and massage therapy. Because they don't fit within the traditional medical system of diagnosis or treatment, CAM practitioners often choose to use “alternative” treatments. However, many CAM therapies also incorporate elements of conventional medicine. One example is acupuncture that uses needles. Others use heat or acupressure.
Some CAM therapies can help with anxiety, stress management, pain relief, relaxation, sleep disorders, insomnia, and stress management. They may improve your general well-being as well as reduce fatigue. Some CAM therapies address specific conditions like fibromyalgia or chronic fatigue syndrome, irritable bowel disease, rheumatoid arthritis, cancer, and diabetes. Other CAM therapies may simply be enjoyable experiences.
Although there is no one definition of CAM, most definitions include at minimum one of these:
- A holistic perspective that takes into account both body, mind, spirit, and environment
- The belief, that mind and body influence and interact
- The belief that illness can be caused by an imbalance in the environment or between the individual and his/her environment
- A treatment that focuses on the whole person instead of just the symptoms
- Combination between Eastern philosophy and Western science
- Methods that treat mind, body, spirit in a holistic way
- Use of natural products rather than synthetic chemicals
- The healing touch
- Mindfulness
- Meditation
- Acupuncture
- Yoga
- Herbal remedies
- Homeopathy
- Chiropractic care
- Massage therapy
- Hypnotherapy
- Spiritual healing
- Biofeedback
- Nutritional counseling
- Energy healing
There are potential risks to certain CAM therapies, in addition to the potential benefits. Incorrectly used, certain CAM therapies could cause serious harm and even death. Some may have side effects that should be weighed against the potential benefits. Before you make a decision about whether to try any CAM, it is important that you discuss the issues with your doctor.
What is Alternative Medicine?
This approach to healing focuses on prevention and not treatment. It also encourages people to become informed consumers actively engaged in improving their health and well-being.
Alternative medicine refers to any system of diagnosis and treatment that does not employ allopathic (conventional) medical practices.
What is holistic medicine's opposite?
Holistic medicine examines the whole person and all its aspects. It is based on the concept that any illness must have multiple causes and requires a combination of treatments for maximum effectiveness.
Holistic medicine doctors believe that prevention is more effective than treatment. To achieve optimal wellness, holistic medicine doctors work closely alongside their patients.
They are trained to spot the root causes and prevent future disease. Holistic physicians consider the entire body and not merely the physical organs. They refer to the whole of being as “the entire body.”
They treat the whole body, not just the skin. The doctor might recommend lifestyle changes, such as diet and exercise. He may also recommend meditation or yoga exercises, herbal supplementation, massage or chiropractic treatment, as well as acupuncture and other forms of alternative medicine.
Why would people with cancer choose to use other methods?
Patients with cancer face many difficulties when trying to manage their illness. Many patients feel defeated and hopeless. Some symptoms include nausea, vomiting, headaches, weight loss, and fatigue.
Additionally, many conventional treatments do not work against cancer cells. It is important that cancer patients look for alternative therapies, such a complementary medicine. Studies have shown that half of all cancer patients have tried alternative treatments at least once.
Some cancer patients choose complementary medicine over chemotherapy, believing it will be easier for them to manage side effects. Also, they may prefer it because it costs less.
Other reasons include the following:
Some patients believe that natural remedies can be used to prevent a repeat.
Many people believe natural remedies can improve their quality of living.
Others believe natural remedies can help reduce your risk of getting again cancer.
Natural remedies are first-line therapy for those who are concerned about side effects from chemotherapy.
Statistics
- The use of alternative medicine in the US has increased, with a 50 percent increase in expenditures and a 25 percent increase in the use of alternative therapies between 1990 and 1997 in America. (en.wikipedia.org)
- category.[111]Edzard Ernst characterized the evidence for many alternative techniques as weak, nonexistent, or negative and in 2011, published his estimate that about 7.4% were based on “sound evidence.” However, he believes that may be an overestimate. (en.wikipedia.org)
- In the 17% in which they disagreed, a third reader agreed with one of the initial readers to set a rating. (en.wikipedia.org)
- According to a 2005 book by a US [116]Institute of Medicine panel, the number of RCTs focused on CAM has risen dramatically. (en.wikipedia.org)
- According to the World Health Organization, 80% of people use herbal medicine worldwide. (webmd.com)
External Links
ncbi.nlm.nih.gov
- BIOFEEDBACK TRAINING, TENSION-TYPEHEADACHE – PubMed
- The Effect of Foot Reflexology on Hospital Anxiety and Depression in Female Older Adults: a Randomized Controlled Trial – PubMed
liebertpub.com
- Games for Health Journal
- The Journal of Alternative and Complementary Medicine – A systematic review of randomized controlled trials involving acupuncture for insomnia treatment
doi.org
pubmed.ncbi.nlm.nih.gov
- PubMed: The rise of complementary and other medicine: A sociological perspective
- PubMed: Holistic medicine – PubMed
How To
How to deal when your girlfriend trusts an alternative medicine.
You can find advice on the internet for people who are caring for someone with mental illness. It is difficult to find information about alternative medicine for someone you love.
It seems like there is a big divide between the two. There are two types of people: those who doubt conventional medicine and those who are open to its benefits.
What happens when you come across someone who believes in alternative treatments for mental health issues?
Because you don’t know where to start, you may feel confused and frustrated. So what do you say to your partner when he tells you he wants to go to an acupuncturist instead of his doctor? Or when she suggests that she would rather eat gluten-free food than take antidepressants?
Asking questions is important. It can save you a lot of pain later.
These are difficult questions to ask without offending the patient. What if your client says he doesn’t believe in doctors? Do you tell him that he shouldn't trust anyone?
Or, what if she tells you that she believes antidepressants don’t work? You can correct her.
Here's where things can get complicated. It can cause further irritation if you point it out that she is wrong.
Or, you can suggest she sees a psychiatrist. This may create more problems than it solves. This could cause her to be upset at you. Perhaps she thinks you are trying her to control the rest of her life.
So what are you supposed to do?
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This blog is a source of general information and discussion on health and related topics. Information and materials on this blog, on the website, or in any of the connected materials are not intended to replace or used as a substitute for the advice of a medical professional, diagnosis, or treatment. This blog does not represent the application of any nursing, medical or other health professional advice or diagnosis. We are unable to diagnose health conditions, offer second opinions or provide specific treatment recommendations via this blog or on our website.
If you or another person is suffering from a medical issue and you are concerned, consult your doctor or seek out other medical professional treatment as soon as possible. Do not disregard medical advice from a professional or delay seeking it due to information you seen on the blog or website or in any of the linked materials. If you're experiencing an emergency medical situation, dial 911 or seek emergency medical assistance on the closest phone immediately.
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By: Dick Benson
Title: Vitamin D and Autism: The Missing Link
Sourced From: alternativemedicine.com/conditions/brain-health/autism/vitamin-d-and-autism-the-missing-link/
Published Date: Sat, 02 Sep 2023 23:12:45 +0000
Frequently Asked Questions
What does holistic mean to you?
Holistic means whole-based. Holistic refers to looking at the whole picture, not just one part. This isn't always possible because we tend not to see things as a whole.
We tend to think in terms of black and white. However, grey comes in a wide range of shades.
Try to look at everything from different perspectives when you work on a project. You should look at it from all sides.
Consider how the whole thing fits together. How do its various elements interact with each other?
You should also ask yourself why the problem is occurring. And don't forget to consider the impact of any change you make.
What's the difference between holistic medicine, traditional medicine, and holistic?
Traditional medicine tends to treat symptoms while holistic medicine treats the entire person. Holistic medicine focuses on the whole person and not just one aspect of a patient's health.
Traditional medicine treats specific organs and systems, such as the brain. Holistic medicine examines the whole body from the inside. It considers the impact of lifestyle choices on overall wellness.
What are some of the benefits of complementary or alternative medicine?
People who feel they do not receive enough help from allopathic medicine may use complementary and alternative medicine (CAM). These therapies include herbs, mind-body treatments such as acupuncture and massage therapy. Because they don't fit within the traditional medical system of diagnosis or treatment, CAM practitioners often choose to use “alternative” treatments. However, many CAM therapies also incorporate elements of conventional medicine. One example is acupuncture that uses needles. Others use heat or acupressure.
Some CAM therapies can help with anxiety, stress management, pain relief, relaxation, sleep disorders, insomnia, and stress management. They may improve your general well-being as well as reduce fatigue. Some CAM therapies address specific conditions like fibromyalgia or chronic fatigue syndrome, irritable bowel disease, rheumatoid arthritis, cancer, and diabetes. Other CAM therapies may simply be enjoyable experiences.
Although there is no one definition of CAM, most definitions include at minimum one of these:
- A holistic perspective that takes into account both body, mind, spirit, and environment
- The belief, that mind and body influence and interact
- The belief that illness can be caused by an imbalance in the environment or between the individual and his/her environment
- A treatment that focuses on the whole person instead of just the symptoms
- Combination between Eastern philosophy and Western science
- Methods that treat mind, body, spirit in a holistic way
- Use of natural products rather than synthetic chemicals
- The healing touch
- Mindfulness
- Meditation
- Acupuncture
- Yoga
- Herbal remedies
- Homeopathy
- Chiropractic care
- Massage therapy
- Hypnotherapy
- Spiritual healing
- Biofeedback
- Nutritional counseling
- Energy healing
There are potential risks to certain CAM therapies, in addition to the potential benefits. Incorrectly used, certain CAM therapies could cause serious harm and even death. Some may have side effects that should be weighed against the potential benefits. Before you make a decision about whether to try any CAM, it is important that you discuss the issues with your doctor.
What is Alternative Medicine?
This approach to healing focuses on prevention and not treatment. It also encourages people to become informed consumers actively engaged in improving their health and well-being.
Alternative medicine refers to any system of diagnosis and treatment that does not employ allopathic (conventional) medical practices.
What is holistic medicine's opposite?
Holistic medicine examines the whole person and all its aspects. It is based on the concept that any illness must have multiple causes and requires a combination of treatments for maximum effectiveness.
Holistic medicine doctors believe that prevention is more effective than treatment. To achieve optimal wellness, holistic medicine doctors work closely alongside their patients.
They are trained to spot the root causes and prevent future disease. Holistic physicians consider the entire body and not merely the physical organs. They refer to the whole of being as “the entire body.”
They treat the whole body, not just the skin. The doctor might recommend lifestyle changes, such as diet and exercise. He may also recommend meditation or yoga exercises, herbal supplementation, massage or chiropractic treatment, as well as acupuncture and other forms of alternative medicine.
Why would people with cancer choose to use other methods?
Patients with cancer face many difficulties when trying to manage their illness. Many patients feel defeated and hopeless. Some symptoms include nausea, vomiting, headaches, weight loss, and fatigue.
Additionally, many conventional treatments do not work against cancer cells. It is important that cancer patients look for alternative therapies, such a complementary medicine. Studies have shown that half of all cancer patients have tried alternative treatments at least once.
Some cancer patients choose complementary medicine over chemotherapy, believing it will be easier for them to manage side effects. Also, they may prefer it because it costs less.
Other reasons include the following:
Some patients believe that natural remedies can be used to prevent a repeat.
Many people believe natural remedies can improve their quality of living.
Others believe natural remedies can help reduce your risk of getting again cancer.
Natural remedies are first-line therapy for those who are concerned about side effects from chemotherapy.
Statistics
- The use of alternative medicine in the US has increased, with a 50 percent increase in expenditures and a 25 percent increase in the use of alternative therapies between 1990 and 1997 in America. (en.wikipedia.org)
- category.[111]Edzard Ernst characterized the evidence for many alternative techniques as weak, nonexistent, or negative and in 2011, published his estimate that about 7.4% were based on “sound evidence.” However, he believes that may be an overestimate. (en.wikipedia.org)
- In the 17% in which they disagreed, a third reader agreed with one of the initial readers to set a rating. (en.wikipedia.org)
- According to a 2005 book by a US [116]Institute of Medicine panel, the number of RCTs focused on CAM has risen dramatically. (en.wikipedia.org)
- According to the World Health Organization, 80% of people use herbal medicine worldwide. (webmd.com)
External Links
ncbi.nlm.nih.gov
- BIOFEEDBACK TRAINING, TENSION-TYPEHEADACHE – PubMed
- The Effect of Foot Reflexology on Hospital Anxiety and Depression in Female Older Adults: a Randomized Controlled Trial – PubMed
liebertpub.com
- Games for Health Journal
- The Journal of Alternative and Complementary Medicine – A systematic review of randomized controlled trials involving acupuncture for insomnia treatment
doi.org
pubmed.ncbi.nlm.nih.gov
- PubMed: The rise of complementary and other medicine: A sociological perspective
- PubMed: Holistic medicine – PubMed
How To
How to deal when your girlfriend trusts an alternative medicine.
You can find advice on the internet for people who are caring for someone with mental illness. It is difficult to find information about alternative medicine for someone you love.
It seems like there is a big divide between the two. There are two types of people: those who doubt conventional medicine and those who are open to its benefits.
What happens when you come across someone who believes in alternative treatments for mental health issues?
Because you don’t know where to start, you may feel confused and frustrated. So what do you say to your partner when he tells you he wants to go to an acupuncturist instead of his doctor? Or when she suggests that she would rather eat gluten-free food than take antidepressants?
Asking questions is important. It can save you a lot of pain later.
These are difficult questions to ask without offending the patient. What if your client says he doesn’t believe in doctors? Do you tell him that he shouldn't trust anyone?
Or, what if she tells you that she believes antidepressants don’t work? You can correct her.
Here's where things can get complicated. It can cause further irritation if you point it out that she is wrong.
Or, you can suggest she sees a psychiatrist. This may create more problems than it solves. This could cause her to be upset at you. Perhaps she thinks you are trying her to control the rest of her life.
So what are you supposed to do?
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